Semantic Computational Models for Polypharmacology: Applications in Drug Repurposing

2023 | HICSS | Citations: 0

Authors: Juric, Radmila; Almami, Eiman; Almami, Btesam; Ahmed, Zaki

Abstract: This paper proposes a computational model based on the first order logic reasoni ... Expand

Abstract: This paper proposes a computational model based on the first order logic reasoning, for managing discoveries in Polypharmacology for the purpose of efficient drug repositioning. The model uses computational reasoning upon advances documented in the published literature and thus is primarily based on the range of discoveries in biomedical science. The idea behind the model is to exploit drugs multiple intended and particularly unintended therapeutical and adverse targets and discover if they can lead us towards drug repurposing. Computational pharmacology is a very complex field, but reasoning upon its concept can bring us closer to the ideal poly pharmacological world of finding, developing and approving multitargeted drugs and use them in drug repurposing. Collapse

Topics: predicate logic Java online learning system artificial intelligence systems development

Methods: ontological modelling natural language processing design artifact computational algorithm literature study

Creating Intelligent Computational Edge through Semantic Mediation

2023 | HICSS | Citations: 0

Authors: Juric, Radmila; Ronchieri, Elisabetta; Suh, Sang

Abstract: This research proposes semantic mediation based on reasoning and the first order ... Expand

Abstract: This research proposes semantic mediation based on reasoning and the first order logic for mediating the best possible configuration of Computational Edge, relevant for software applications which may benefit for running computations with proximity to their data sources. The mediation considers the context in which these applications exist and exploits the semantic of that context for decision making on where computational elements should reside and which data they should use. The application of semantic mediation could address the initiative to accommodate algorithms from predictive and learning technologies, push AI towards computational edges and potentially contribute towards creating a computing continuum. Collapse

Topics: cloud computing mobile system internet of things edge computing artificial intelligence

Methods: ontological modelling computational algorithm literature study literature sample

An Automatic Ontology Generation Framework with An Organizational Perspective

2020 | HICSS | Citations: 0

Authors: Elnagar, Samaa; Yoon, Victoria; Thomas, Manoj A

Abstract: Ontologies have been known for their powerful semantic representation of knowled ... Expand

Abstract: Ontologies have been known for their powerful semantic representation of knowledge. However, ontologies cannot automatically evolve to reflect updates that occur in respective domains. To address this limitation, researchers have called for automatic ontology generation from unstructured text corpus. Unfortunately, systems that aim to generate ontologies from unstructured text corpus are domain-specific and require manual intervention. In addition, they suffer from uncertainty in creating concept linkages and difficulty in finding axioms for the same concept. Knowledge Graphs (KGs) has emerged as a powerful model for the dynamic representation of knowledge. However, KGs have many quality limitations and need extensive refinement. This research aims to develop a novel domain-independent automatic ontology generation framework that converts unstructured text corpus into domain consistent ontological form. The framework generates KGs from unstructured text corpus as well as refine and correct them to be consistent with domain ontologies. The power of the proposed automatically generated ontology is that it integrates the dynamic features of KGs and the quality features of ontologies. Collapse

Topics: knowledge representation web page predicate logic knowledge graph social media

Methods: ontological modelling computational algorithm domain ontology DOLCE ontology WordNet

Understanding the Scene Data- Pavement Area Grouping in Images

2017 | International Conference on Information Systems | Citations: 4

Authors: Chatterjee, Sromona; Hildebrandt, Björn; Kolbe, Lutz M.

Abstract: Modern societies are clearly en route towards digitalization. Natural scene imag ... Expand

Abstract: Modern societies are clearly en route towards digitalization. Natural scene images particularly could provide many value added applications and services. In this paper, we address the challenges that arise with pavement detection in rural, urban, and unstructured scenes. We use an approach combining region similarity, split and merge, and pairwise assignment, to merge image regions according to a homogeneity criteria, and group pavement regions in images. Homogeneity criteria is based on color and texture feature types. In successive steps a distance matrix based on varying kernel is created. The approach is numerically simple, yet retains the ability to merge similar regions. Assignment with Hungarian method is used to achieve hierarchical region merging. As a result, pavement area grouping could be handled. Evaluations on relevant datasets show that our approach allows successful merging and recognition of image regions belonging to the pavement area for various scenes and surface types. Collapse

Topics: predicate logic global navigation satellite system system integration Python open source

Methods: AdaBoost k-nearest neighbor computational algorithm support vector machine machine learning

Normative requirements for regulatory compliance: An abstract formal framework

2016 | Information Systems Frontiers | Citations: 2

Authors: Hashmi, Mustafa; Governatori, Guido; Wynn, Moe Thandar

Abstract: By definition, regulatory rules (in legal context called norms) intend to achiev ... Expand

Abstract: By definition, regulatory rules (in legal context called norms) intend to achieve specific behaviour from business processes, and might be relevant to the whole or part of a business process. They can impose conditions on different aspects of process models, e.g., control-flow, data and resources etc. Based on the rules sets, norms can be classified into various classes and sub-classes according to their effects. This paper presents an abstract framework consisting of a list of norms and a generic compliance checking approach on the idea of (possible) execution of processes. The proposed framework is independent of any existing formalism, and provides a conceptually rich and exhaustive ontology and semantics of norms needed for business process compliance checking. Apart from the other uses, the proposed framework can be used to compare different compliance management frameworks (CMFs). Collapse

Topics: business process management evaluation criteria communication service infrastructure declarative language top management support

Methods: business process modeling modeling language computational algorithm Petri net business process model and notation

On the Discovery of Declarative Control Flows for Artful Processes

2015 | ACM Transactions on Management Information Systems | Citations: 0

Authors: Ciccio, Claudio Di; Mecella, Massimo

Abstract: Artful processes are those processes in which the experience, intuition, and kno ... Expand

Abstract: Artful processes are those processes in which the experience, intuition, and knowledge of the actors are the key factors in determining the decision making. They are typically carried out by the “knowledge workers,” such as professors, managers, and researchers. They are often scarcely formalized or completely unknown a priori. Throughout this article, we discuss how we addressed the challenge of discovering declarative control flows in the context of artful processes. To this extent, we devised and implemented a two-phase algorithm, named MINERful. The first phase builds a knowledge base, where statistical information extracted from logs is represented. During the second phase, queries are evaluated on that knowledge base, in order to infer the constraints that constitute the discovered process. After outlining the overall approach and offering insight on the adopted process modeling language, we describe in detail our discovery technique. Thereupon, we analyze its performances, both from a theoretical and an experimental perspective. A user-driven evaluation of the quality of results is also reported on the basis of a real case study. Finally, a study on the fitness of discovered models with respect to synthetic and real logs is presented. Collapse

Topics: electronic mail Java knowledge base open source operating system

Methods: computational algorithm business process modeling event log case study experiment

Organizational Obsolescence, Drifting Tastes, and Age Dependence in Organizational Life Chances

2015 | Organization Science | Citations: 0

Authors: Le Mens, Gaël; Hannan, Michael T.; Pólos, László

Abstract: Various patterns of age dependence in hazards of organizational failure have bee ... Expand

Abstract: Various patterns of age dependence in hazards of organizational failure have been documented: liabilities of newness, adolescence, and obsolescence. Prior efforts at providing a unified theory that can accommodate these patterns as special cases have not dealt properly with obsolescence. We tackle this problem by proposing a new model that builds on the most recent unification attempt while integrating the core intuition behind obsolescence: organizations have trouble adapting to drifting environments, which leads to declining performance and, in turn, to decreasing viability. In doing so, we develop a comprehensive representational framework to precisely characterize obsolescence. Our perspective builds on recent theory and research that treats categories as constructions by audiences. We characterize environmental drift as changing audience tastes in a multidimensional feature space and organizational inertia as a decreasing ability for producers to move quickly in that space. This combination creates obsolescence with aging. We then integrate this perspective with prior theory to make novel predictions regarding the age dependence in life chances over the life courses of organizations. We also show how the predictions of our theory can be tested empirically by adapting Levinthal’s random walk model [Levinthal DA (1991) Random walks and organizational mortality. Admin. Sci. Quart. 36(3):397–420] to incorporate the possibility of organizational obsolescence. Collapse

Topics: organizational productivity innovation management organization learning predicate logic

Methods: theory development literature study

Information System Design Space for Sustainability

2015 | DESRIST | Citations: 0

Authors: Mustaquim, Moyen Mohammad; Nyström, Tobias

Abstract: The interdisciplinary nature of human-computer interaction (HCI) makes it possib ... Expand

Abstract: The interdisciplinary nature of human-computer interaction (HCI) makes it possible to contribute towards an improved thinking in design and the process of information system designs. It is, however, a challenging aim, because the transformation of different gathered knowledge from HCI to information system designers is not easy, there being multiple design solutions available. In this paper a design space for designing an information system aimed at sustainability is introduced and discussed. The design space could be seen as part of a new design process, or correlating with an existing design setting and consisting of nine different components that are explored elaborately through a design space analysis. Differently selected dimensions of the proposed design space imitate knowledge from HCI and the result thus reflects a support for successfully transferring knowledge from HCI to the information system (IS) designers for improving a design process. Collapse

Topics: human computer interaction usability systems design predicate logic problem solving

Methods: design process reference modelling cross sectional research design science

Multilevel Modeling: Toward a New Paradigm of Conceptual Modeling and Information Systems Design

2014 | Business & Information Systems Engineering | Citations: 0

Authors: Frank, Ulrich

Abstract: The paper presents a novel approach to conceptual modeling that serves to addre ... Expand

Abstract: The paper presents a novel approach to conceptual modeling that serves to address a fundamental conflict inherent in designing languages and information systems. It not only promises to improve the economics of developing and using models and respective software systems, but also to foster the empowerment of users by providing them with specific languages that correspond directly to the perspective on a domain they are used to. Collapse

Topics: enterprise modelling information technology infrastructure Java declarative language predicate logic

Methods: metamodel hierarchical linear modeling conceptual modelling design science design artifact

Improving the Semantics of Conceptual-Modeling Grammars: A New Perspective on an Old Problem

2013 | International Conference on Information Systems | Citations: 0

Authors: Clarke, Roger; Burton-Jones, Andrew; Weber, Ron

Abstract: A core activity in information systems development involves understanding the co ... Expand

Abstract: A core activity in information systems development involves understanding the conceptual model of the domain that the information system supports. Any conceptual model is ultimately created using a conceptual-modeling (CM) grammar. Accordingly, just as high quality conceptual models facilitate high quality systems development, high quality CM grammars facilitate high quality conceptual modeling. This paper seeks to provide a new perspective on improving the quality of CM grammar semantics. For the past twenty years, the leading approach to this topic has drawn on ontological theory. However, the ontological approach captures just half of the story. It needs to be coupled with a logical approach. We show how ontological quality and logical quality interrelate and we outline three contributions of a logical approach: the ability to see familiar conceptual-modeling problems in simpler ways, the illumination of new problems, and the ability to prove the benefit of modifying CM grammars. Collapse

Topics: knowledge representation predicate logic automated reasoning

Methods: conceptual modelling ontological modelling entity relationship modeling design science survey

Theories: theory of everything theory of ontological expressiveness